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Bar-Ilan University Online Newsletter
Newsletter No. 5, October 2016

Trailblazing Study into Tourette Syndrome

Izhar Bar-GadInternationally recognized for his pioneering research into Tourette syndrome, BIU neurophysiologist Prof. Izhar Bar-Gad has uncovered the mechanism that determines the timing of tics associated with the disorder that affects millions of children and adults worldwide. This is an important step toward understanding and hopefully, also controlling the involuntary head jerking, rapid blinking, “barking” and even cursing and rib punching, which exacerbates their daily lives.  

Bar-Gad of BIU’s Gonda Multidisciplinary Brain Research Center elucidates: “When we talk about Tourette, there are two questions at the heart of our research: where and when. The ‘where’ relates to which organ in the body will be activated by the disorder and the ‘when’ relates to the timing mechanisms of the individual tics.”

Several years ago Bar-Gad developed a model of Tourette Syndrome (TS) as part of a study funded by the Tourette Association of America, and later, his team succeeded in modeling the syndrome in rats. At about that time, his investigations yielded an answer to the enigma of “where” – in which organ the tic will occur. Now Bar-Gad has co-authored an Israeli study – recently published in the Journal of Neuroscience – which provides the answer to the question of “when.”

He implicates the striatum – which is part of the basal ganglia, which controls a variety of functions in the brain such as releasing voluntary motor movements, procedural learning, routine behaviors or “habits”, eye movements, cognition and emotion. “One of the striatum’s important roles is preventing involuntary movements. It’s an area that ordinarily is flooded with inputs which come from the area of the cortex, which carry out many and varied simultaneous motoric potential actions. The striatum helps choose movements by suppressing most of the signals coming into the cortex and enables the correct selection of the desired movement. Without a mechanism like this, the body would lose its motor control.”

Bar-Gad’s team conducted a precise analysis of neuron activity in the brains of animal models with involuntary movements. “Basically there is a mechanism of flooding and release,” he explains. “You can compare this to a cup leaning on its side that empties out every time it fills up completely. What happens in the production of a tic is that the striatum takes in more and more nerve cell messages until it reaches a certain threshold at which it dumps the “overload “– the involuntary movement known as a tic.  The moment the tic occurs there is a recalibration and the dynamic begins again, and so on.  In our study we clearly show the processes of accumulation and release.

“In effect the body parts in which tics will appear are an outcome of the areas of striatum that are affected,” says Bar-Gad, whose lab in an earlier study was able to map the striatum according to its influence on the motor activity of various body parts. “For example, if the part is connected to the activity of the eye, flooding it with signals from the cortex will cause blinking.

“Even though the syndrome was discovered more than a hundred years ago, research and science have not given it very much serious attention,” says Bar-Gad, who’s intent on changing that.  The Society for Neuroscience’s 2016 annual conference in San Diego features thousands of talks and posters on Parkinson’s, Alzheimer’s, and other brain disorders but only one presentation related to Tourette syndrome, to be given by the BIU Gonda Center’s Prof. Bar-Gad.

Also in this issue:

President's Message - Reflections for the New Year »

BIU-YU Summer Science Interns Dig Israel

Taking time out from their intensive BIU lab internships, over two dozen undergrads from YU, Cornell, and other American universities join the Tell es-Safi/Gath dig (directed by BIU's Prof. Aren Maeir) for a day. The science majors enthuse about the seven-week joint BIU-Yeshiva University (YU) program which enables them to engage in cutting edge research while being mentored by top Israeli scientists in nanotechnology, brain research, engineering, life sciences, math, chemistry and psychology.

While honing research skills, they strengthen ties with Israel and become acquainted with creative advancements via field trips to Israel Aerospace Industries, Teva Pharmaceuticals, and the Agriculture Research Organization (Volcani Center).

The program, directed by Prof. Ari Zivotofsky (far left) of BIU's Gonda Multidisciplinary Brain Research Center, benefits from the generosity of Dr. Mordecai D. Katz, Honorary Chairman of the BIU Board of Trustees, and from the J. Samuel Harwit Z"L and Manya Harwit-Aviv Charitable Trust.

BIU Bible Scholar Exposes King David's Elite Commander

After an ancient clay jug found in the biblical Sha'arayim — where David fought Goliath — was painstakingly pieced together, a noted BIU Bible scholar sheds light on the inscription "Eshbaal son of Beda." Prof. Emeritus Moshe Garsiel, an authority on King David's history, believes the mysterious persona was the Sha'arayim fortress commander and co-founder of an elite military unit in the Kingdom of Judah.

 read more »

 

Representing Israel in the Rio Paralympics

Competing in wheelchair tennis at the Rio 2016 Paralympics, BIU alumnus Itai Erenlib and teammate Shraga Weinberg just barely missed out on a bronze medal in the men's Quad Doubles after falling in a third-set tie-breaker with the British team. But the near win itself is a cause for celebration as it attests to Erenlib's tenacious efforts to overcome a life-changing injury incurred while serving as an IDF officer in the Paratroopers' Special Forces.

 read more »

 

A Wealth of Friendship

The landmark US defense aid package signed in Sept. is an important event for Israel for three reasons, says Maj. Gen. (res.) Yaakov Amidror of BIU's Begin-Sadat Center for Strategic Studies. 1) It indicates the depth of the American leadership's commitment to Israel's security, despite differences of opinion between the two countries. 2) It allows the IDF to sustain its multiyear plans to bolster capabilities in every field. 3) It signals to all those plotting against Israel that Israel's friendship with the US remains strong.

 read more »

 

Scholars & Sources:
The Message of the Fast of Gedaliah

What is the significance of the Fast of Gedaliah, which we mark on the day following Rosh Hashana? How is this fast different from the others? Sharing her insights is Dr. Tova Ganzel, Director of the Midrasha at the Jesselson Institute for Advanced Torah Studies, which empowers women to play an influential role in the evolving Jewish world.

 read more »

 
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