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Bar-Ilan University Online Newsletter
Newsletter No. 2, April 2016

Groundbreaking Research Implicates RNA in Causing Cancer

A novel study conducted by BIU scientists points to an exciting new direction in cancer research.

Dr Erez Levanon
Dr. Erez Levanon

Until very recently, the war against cancer has focused on cancerous mutations in DNA, the cell’s genetic “blueprint.” But now new research shows that RNA, DNA’s genetic envoy which is instrumental in creating proteins, might also have a key role in the development of the disease.

Research conducted by Dr. Erez Levanon of BIU’s Mina and Everard Goodman Faculty of Life Sciences and Tel Aviv University Prof. Eli Eisenberg, that was recently published in Cell Reports (at the same time that a US group published identical findings in Cancer Cell), demonstrates a connection between RNA editing (which occurs when the “message” encoded by a DNA sequence is changed without accompanying changes in the DNA itself) and cancer. “We found that in many cancerous tumors, the RNA editing mechanism simply goes wild and creates many mutations,” Levanon says.

RNA Mechanism “Goes Wild”

The action of RNA editing and creating mutations seen in cancer patients is conducted by the enzyme ADAR — which is involved in defending the body against viruses and infections. “As soon as there is an infectious path in some tumors the action of the Adar enzyme increases and causes a chain reaction that expresses itself in the many RNA mutations that we have found,” explains Levanon.

RNA has been largely ignored by cancer researchers who have concentrated on DNA in the cell nucleus. “We used the same process that’s done with DNA to locate mutations but only in RNA,” explains Levanon, adding, “We looked at the information of close to a thousand cancerous tumors and found dozens of mutations that differentiated between cancer patients and healthy individuals and between different types of cancer.”

Far Reaching Implications

Performed in the framework of BIU student’s Nurit Paz-Yaacov’s postdoctoral research, they focused on nine types of common tumors (e.g. breast cancer, lung cancer, liver cancer). “Because the Adar enzyme is in every cell, we hope in the future to be able to direct it to place where there is a mutation and to fix it or change it,” says Levanon. These new research findings are significant markers, and will undoubtedly pave a new way, say the scientists, adding that their research is only at the beginning, but its implications might be far reaching.

Also in this issue:

President's Message - From Purim to Pesach »

We are the Champions!

Debating key global issues, BIU Model UN team members win best delegates at the 2016 international competition in Madrid where they role-played Mexico in the Historical UN Security Council and Germany in the ECOSOC (Economic and Social Council).

Defining the State of Israel:
Jewish and/or Democratic?

"Some argue that the values of the Jewish state and the values of the democratic state cannot co-exist. I don't believe this, and this has not been the position of the Supreme Court over the years," said Supreme Court President Miriam Naor, in addressing a conference on Jewish and Democratic Law hosted by Bar-Ilan University's Faculty of Law, which was supported by the Zahava and Moshael J. Straus Family Foundation.

 read more »

 

Landmark Biblical Finds and a Spicy Discovery

Unearthing one of the top ten archaeological discoveries of 2015, BIU Land of Israel Studies & Archaeology faculty have also made some spicy discoveries about the Philistine impact on Israeli flora in antiquity.

 read more »

 

Jordanian-Israeli Relations:
Above Board & Beneath the Surface

During a recent visit to Amman, Dr. Elad Ben-Dror, of the Department of Middle Eastern Studies, steps into a souvenir shop and finds a vast gap between public and underlying attitudes toward Israel. Here's his personal account.

 read more »

 

Scholars & Sources:
Biblical Creation and Modern Science

Where did the universe come from? Physics Prof. Nathan Aviezer explores how creation ex nihilo is now accepted as scientific fact.

 read more »

 
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